As of 2014 there were no medications effective for idiopathic tinnitus.[3][73] There is not enough evidence to determine if antidepressants[81] or acamprosate are useful.[82] While there is tentative evidence for benzodiazepines, it is insufficient to support usage.[3] Usefulness of melatonin, as of 2015, is unclear.[83] It is unclear if anticonvulsants are useful for treating tinnitus.[3][84] Steroid injections into the middle ear also do not seem to be effective.[85][86]

A common cause of tinnitus is inner ear hair cell damage. Tiny, delicate hairs in your inner ear move in relation to the pressure of sound waves. This triggers cells to release an electrical signal through a nerve from your ear (auditory nerve) to your brain. Your brain interprets these signals as sound. If the hairs inside your inner ear are bent or broken, they can "leak" random electrical impulses to your brain, causing tinnitus.