We provide here a list of known ototoxic drugs and herbs that have been known to cause or exacerbate tinnitus. This list is for educational purposes only and is available as a resource to you to use in your discussions with your health care professional. We thank doctor Neil Bauman, Ph.D., for his expertise in this area and for compiling this list for us.
To answer your question about NAC (N-acetyl-L-cysteine), I’ve seen little evidence suggesting that is effective for tinnitus. Instead – though the research is very limited – multiple anecdotal reports describe success with the herb ginkgo biloba. Try taking two tablets of standardized extract of ginkgo three times a day with meals (no more than a total dose of 240 mg a day). Ginkgo may work by increasing blood circulation to the head and neck. Give it at least a two-month trial. You might also explore cranial therapy, a gentle manipulative technique performed by osteopathic physicians. This approach seems to take the pressure or irritation off the auditory nerves. If high blood pressure is responsible for your tinnitus, try to get that under control through diet, exercise, and weight loss or medication if necessary.
Tinnitus is commonly thought of as a symptom of adulthood, and is often overlooked in children. Children with hearing loss have a high incidence of tinnitus, even though they do not express the condition or its effect on their lives.[100] Children do not generally report tinnitus spontaneously and their complaints may not be taken seriously.[101] Among those children who do complain of tinnitus, there is an increased likelihood of associated otological or neurological pathology such as migraine, juvenile Meniere’s disease or chronic suppurative otitis media.[102] Its reported prevalence varies from 12% to 36% in children with normal hearing thresholds and up to 66% in children with a hearing loss and approximately 3–10% of children have been reported to be troubled by tinnitus.[103]

Treatment of the underlying primary disorder may help to improve or cure rhythmic tinnitus. For example, the treatment of blood vessel disorders (e.g. dural arteriovenous shunts) can include certain medications or surgery. A surgical procedure known as sinus wall reconstruction can successfully treat pulsatile tinnitus due to sigmoid sinus diverticulum and dehiscence. In fact, most individuals have experienced complete resolution of their tinnitus following this surgery. Surgery may also be necessary for rare cases of pulsatile tinnitus caused by a tumor.
Most experts refer to tinnitus as the condition that causes ringing in the ears, however other abnormal sounds and sensations can also be attributed to tinnitus. The definition of tinnitus is “the perception of noise or ringing in the ears.” Some also describe this condition as “hearing sounds in the ears when no external sound is present.” Although tinnitus is only a significant problem for about 1 percent to 5 percent of the population, up to 10 percent to 15 percent of all children and adults are believed to experience ringing in the ears at least from time to time.

Some patients choose to get involved in “tinnitus retraining,” which involves wearing a device in the ears that provides soothing music or noise, along with undergoing counseling. The goal is to help your body and brain learn to get accustomed to tinnitus noise, which reduces your negative reactions to unwanted sounds. Support and counseling during the process can be helpful for reducing anxiety. Researchers are now learning more about the benefits of coherent cognitive behavioral therapy interventions to help treat distress associated with tinnitus. (3)
There is a growing body of evidence suggesting that some tinnitus is a consequence of neuroplastic alterations in the central auditory pathway. These alterations are assumed to result from a disturbed sensory input, caused by hearing loss.[28] Hearing loss could indeed cause a homeostatic response of neurons in the central auditory system, and therefore cause tinnitus.[29]
An assessment of hyperacusis, a frequent accompaniment of tinnitus,[56] may also be made.[57] The measured parameter is Loudness Discomfort Level (LDL) in dB, the subjective level of acute discomfort at specified frequencies over the frequency range of hearing. This defines a dynamic range between the hearing threshold at that frequency and the loudnes discomfort level. A compressed dynamic range over a particular frequency range is associated with subjectve hyperacusis. Normal hearing threshold is generally defined as 0–20 decibels (dB). Normal loudness discomfort levels are 85–90+ dB, with some authorities citing 100 dB. A dynamic range of 55 dB or less is indicative of hyperacusis.[58][59]
Almost every ENT, audiology practice, and hearing aid dispenser who claims to offer tinnitus treatment only offers one solution: hearing aids. While amplification may help some, only 50% of people living with tinnitus experience hearing loss that affects their understanding of speech, which means hearing aids are ineffective. At Sound Relief, we offer only evidence-based options like sound therapy and have seen countless patients experience life-changing results.
Widex employs fractal tone technology, so that the sounds you hear are predictable but not repeating. Your audiologist can choose between an assortment of “musical tones” known as “Zen styles,” which are random and chime-like. Your audiologist can adjust the tones’ pitch, tempo, and volume. If employed correctly, Widex Zen Therapy can help re-wire your brain and make your tinnitus less noticeable.
When a medication is ototoxic, it has a toxic effect on the ear or its nerve supply. In damaging the ear, these drugs can cause side effects like tinnitus, hearing loss, or a balance disorder. Depending on the medication and dosage, the effects of ototoxic medications can be temporary or permanent. More than 200 prescription and over-the-counter medicines are known to be ototoxic, including the following:
Seek treatment for hearing problems. If you’re experiencing difficulty hearing, talk to your physician and seek help from an otolaryngologist (an ear, nose throat specialist) or an audiologist. In addition to addressing any underlying health issue and improving your quality of life, improving your hearing can make tinnitus less noticeable and less bothersome, during the day and at night when you’re trying to sleep.
The patients were assessed at the start of the study for their hearing ability and the severity of their tinnitus. The researchers assessed the degree of severity using established questionnaires, which looked at health-related quality of life, the psychological distress associated with tinnitus and how far it impaired their functioning. Using this information, researchers divided participants into four groups ranked on the severity of their condition.

Somatic tinnitus is caused, worsened, or otherwise related to your body’s own sensory system. Sensory signals coming from various parts of the body are disrupted, causing a spasm that produces tinnitus. Those who have somatic tinnitus usually have it in only one ear. Depending on the root cause your doctor may come up with treatment options to alleviate the symptoms.


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Microvascular compression may sometimes cause tinnitus. According to Levine (2006) the quality is similar to a "typewriter", and it is fully suppressed by carbamazepine. It seems to us that response to carbamazepine is not a reliable indicator of microvascular compression as this drug stabilizes nerves and lowers serum sodium. Nevertheless, this quality of tinnitus probably justifies a trial of oxcarbamazine (a less toxic version of carbamazepine).
It is important to follow the doctor's directions in obtaining further evaluations and tests for your tinnitus. You may need an appointment with an ear, nose, and throat specialist (otolaryngologist) or an audiologist for further testing. It is important to follow up on these recommendations when they are made to confirm that your tinnitus is not caused by another illness.

When TRT was developed in the 1980s by neuroscientist Dr. Pawel Jastreboff (now at Emory University in Atlanta), it was designed to be administered according to a strict protocol. Today, the term TRT is being used to describe modified versions of this therapy, and the variations make accurate assessment of its effectiveness difficult. Individual studies have reported improvements in as many as 80% of patients with high-pitched tinnitus. In a Cochrane review of the one randomized trial that followed Jastreboff's protocol and met the organization's standards, TRT was much more effective in reducing tinnitus severity and disability than a technique called masking (see below).
A number of vital tasks carried out during sleep help maintain good health and enable people to function at their best. Sleep needs vary from individual to individual and change throughout your life. The National Institutes of Health recommend about 7-9 hours of sleep each night for older, school-aged children, teens, and most average adults; 10-12 for preschool-aged children; and 16-18 hours for newborns. There are two stages of sleep; 1) REM sleep (rapid-eye movement), and 2) NREM sleep (non-rapid-eye movement). The side effects of lack of sleep or insomnia include:

Individuals were recruited from within and around Hamilton, Ontario via online announcements and audiology clinics. Applicants were initially interviewed via telephone to screen for all inclusion and exclusion criteria for the study in order to determine whether they qualified for on-site screening. The on-site screening, and characterization of participants’ hearing thresholds and tinnitus profiles were conducted in a lab at McMaster University using a computer-based tinnitus assessment tool. Participants were randomly allocated to the treatment or placebo-control group. The assignment of the treatment or placebo music package was completed by a distributor site independent of the research study site. Participants and research personnel were blinded to which music package the participants received.


Miracle-Ear hearing aids come in a wide variety of styles and solutions. Our hearing devices can be custom-molded to fit directly in your ear canal, or designed to fit comfortably behind your ear. Whether you're trying to find the most powerful solution, the most inconspicuous, or are interested in tinnitus treatment, we've got the right solution for you.
Tinnitus sufferers have tried many alternative therapies but often to no avail. Some have heard of success stories involving the use of certain vitamins, minerals, herbal preparations, or even a change in diet, but often did not experience personal success in treating tinnitus using such options. Unfortunately, no studies to date have been able to associate such treatments to any real benefits. While much of the existing research have been dedicated to helping us understand tinnitus and its etiological underpinnings, there are currently very few treatments that are clinically validated. Of the few that conducted clinical studies to evaluate the effectiveness, most did not use rigorous clinical methods such as controlling for placebo effects or double-blinding to ensure the integrity of the data and to eliminate any sources of bias. Tinnitus sufferers who access such treatments often do not experience relief from their tinnitus. As a result, tinnitus sufferers often experience confusion, frustration, a loss of hope, and skepticism after having invested time and money on available treatment options.
If you’re struggling with tinnitus and experience anxiety or depression relating to your condition, cognitive behavioural therapy is a form of counselling that helps you to cope and readjust your negative feelings. Tinnitus retraining therapy (TRT) can also be used in conjunction with CBT, harnessing the body's natural ability to tune out sounds and make it part of your subconscious mind rather than at the forefront.
Now make your toes as tight as you can, really scrunch them up. Hold them like this for a moment – and relax. Now do the same with your ankles, then your calf muscles, your thighs… work all the way up your body to your head, making sure you tense, hold for a moment, and then release the tension. Once you’ve done this with your whole body, focus again on your breathing – notice the rhythm, it should be even and calm.
The patients were assessed at the start of the study for their hearing ability and the severity of their tinnitus. The researchers assessed the degree of severity using established questionnaires, which looked at health-related quality of life, the psychological distress associated with tinnitus and how far it impaired their functioning. Using this information, researchers divided participants into four groups ranked on the severity of their condition.

Tinnitus usually comes in the form of a high-pitched tone in one or both ears, but can also sound like a clicking, roaring or whooshing sound. While tinnitus isn't fully understood, it is known to be a sign that something is wrong in the auditory system: the ear, the auditory nerve that connects the inner ear to the brain, or the parts of the brain that process sound. Something as simple as a piece of earwax blocking the ear canal can cause tinnitus, but it can also arise from a number of health conditions. For example, when sensory cells in the inner ear are damaged from loud noise, the resulting hearing loss changes some of the signals in the brain to cause tinnitus.
Before long, you’re both mentally and physically stimulated in ways that make it even harder to relax and fall asleep. Like any other form of anxiety, stress about falling asleep creates mental arousal, bringing your brain to alertness. And it also creates physical arousal, raising heart rate and body temperature. This kind of anxiety can lead to behaviors that further undermine sleep, including:
Everything you need to know about acoustic neuroma Acoustic neuroma is a benign tumor affecting nerves between the inner ear and the brain. It can lead to hearing loss, tinnitus, and loss of balance. This MNT Knowledge Center article explores the treatments, symptoms, and causes of acoustic neuroma, as well as how the condition may become more severe and complicate. Read now
This well-designed study found that using CBT alongside elements of standard therapy can help patients with tinnitus of varying severity. However, the differences in outcomes between the two groups were quite small, and this technique can only help manage tinnitus rather than curing it, as some papers implied. Also, the patients in the study were followed for only 12 months, so it is unclear whether this approach can help in the longer term.
In some cases, a special audiologic device, which is worn like a hearing aid, may be prescribed. These devices, called masking agents, emit continuous, low-level white noises that suppress the tinnitus sounds. In some cases, a hearing aid may be recommended to help to suppress or diminish the sounds associated with tinnitus. A combination device (masker plus hearing aid) may also be used. Masking devices provide immediate relief by reducing or completely drowning out the tinnitus sound. However, when the masking device is removed, the tinnitus sound remains.

Objective tinnitus is very rare. It can be heard by a doctor either using a stethoscope or by listening very closely to your ear. It occurs rarely and may due to involuntary muscle contractions or vascular deformities. The sound is often described as pulsating and may be heard in time with your heartbeat. Objective tinnitus usually has a determinable cause and disappears when treated by surgery or other medical intervention.
Tinnitus matching is helpful to identify the frequency and intensity of the tinnitus. This is a simple procedure in which the audiologist adjusts a sound until a patient indicates that it is the same as their tinnitus.  Most patients match their tinnitus to the region of their hearing loss (Konig et al, 2006; Mahboubi et al, 2012). Unfortunately, the "gap detection test", does not work to confirm tinnitus in humabs (Boyen et al, 2015).
Experts recommend that patients with severe tinnitus become educated about tinnitus and how they best deal with its symptoms. This can include learning about biofeedback in order to control stress and your reaction to tinnitus sounds, talking with a counselor, or joining a support group. Coping strategies are most useful for managing emotional side effects of tinnitus, such as anxiety, trouble sleeping, lack of focus and depression.
Vertigo is the sensation of spinning or rocking, even when someone is at rest. Vertigo may be caused by a problem in the brain or spinal cord or a problem within in the inner ear. Head injuries, certain medications, and female gender are associated with a higher risk of vertigo. Medical history, a physical exam, and sometimes an MRI or CT scan are required to diagnose vertigo. The treatment of vertigo may include:

The results were calculated using a measure called “effect size”, which is a way of quantifying the size of the difference between the two groups. For the difference in quality of life scores between groups, the effect size was calculated to be 0.24. This can be interpreted as a “small” effect. In other words, treatment including CBT gave a small improvement in quality of life compared with usual care.

Tinnitus (pronounced ti-nə-təs or tə-nī-təs) is the conscious awareness of a sound in your ears or head not caused by an external noise. Too often associated with hearing loss, the fact is more than 50 percent of people living with tinnitus don’t have measurable hearing loss. Since there are many causes, tinnitus can be associated with a variety of health problems.

^ Langguth B, Goodey R, Azevedo A, et al. (2007). "Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006". Tinnitus: Pathophysiology and Treatment. Progress in Brain Research. 166. pp. 525–36. doi:10.1016/S0079-6123(07)66050-6. ISBN 978-0444531674. PMC 4283806. PMID 17956816.

When we hear, sound waves travel through the ear into the cochlea, our hearing organ in the inner ear. The cochlea is lined with thousands of tiny sound-sensing cells called hair cells. These hair cells change the sound waves into electrical signals. The hearing nerve then sends these electrical signals to the hearing part of the brain, which analyses them and recognises them as sound.
Cartoon of the middle ear showing muscles that attach to ossicles (ear bones), and ear drum. The stapedius is attached to the stapes (of course -- horseshoe object above), while the tensor tympani is attached to the ear drum. While useful, be aware that there are multiple errors in this illustration from Loyola Medical School. With permission, from: http://www.meddean.luc.edu/lumen/meded/grossanatomy/dissector/mml/images/stap.jpg
Masking Devices. Similar to the white noise machines listed above, there are now masking devices that can be worn in the ear, just like a hearing aid, that do almost the same thing. They produce low-level white noise that can suppresses your tinnitus symptoms by training your brain to focus on them instead of the ringing in your ears. These are perfect if you can’t always have a white noise machine running near you.
From amongst the many treatments for tinnitus, you’re certain to find a solution that helps you live a more comfortable life, free of the frustration of tinnitus. Although a definitive cure is not currently available, these tools can help you manage your tinnitus and minimize its influence on your life. If you work closely with an experienced tinnitus specialist, they can help you determine which course of action is best for you.
Can an iPhone app truly relieve tinnitus? Believe it or not, the answer is yes. The ReSound LiNX2 app utilizes a combination of sound therapy and relaxation exercises to reduce the severity of tinnitus. The convenient app can be used in combination with hearing instruments, which are small but strong. This groundbreaking program transforms your iPhone into a remote control for your hearing aid.

Tinnitus Control. As mentioned above, Tinnitus Control has the best success ratio, at suppressing the symptoms of tinnitus, than any other OTC medication. This is achieved through their proprietary blend of the following active ingredients: arnica, chininum sulphuricum, ferrum metallicum, kali phosphoricum, natrum sulphuricum, pulsatilla, silicea, thiosinaminum, garlic and gingko biloba.


Once the music package (MP3 player preloaded with assigned music tracks and headphones) was ready, participants were briefed on safe listening levels, and were instructed to complete a weekly log book to record their listening duration and frequency. The algorithms which modified the music provided to participants are built into proprietary software that was developed internally by Sound Options Tinnitus Treatments Inc. The modified and placebo music packages consisted of 4 hours of classical music.
When there does not seem to be a connection with a disorder of the inner ear or auditory nerve, the tinnitus is called nonotic (i.e. not otic). In some 30% of tinnitus cases, the tinnitus is influenced by the somatosensory system, for instance people can increase or decrease their tinnitus by moving their face, head, or neck.[27] This type is called somatic or craniocervical tinnitus, since it is only head or neck movements that have an effect.[25]
In persons with pulsatile tinnitus, additional tests maybe proposed to study the blood vessels and to check the pressure inside the head. Gentle pressure on the neck can be performed to block the jugular vein but not the carotid artery. The Valsalva maneuver reduces venous return by increasing intrathoracic pressure. If there is a venous hum, this usually abates or improves markedly. If the pulsation is arterial, these tests have no effect.
The similarities between chronic pain and tinnitus have led researchers to develop a mindfulness-based tinnitus stress reduction (MBTSR) program. The results of a pilot study, which were published in The Hearing Journal, found that participants of an eight-week MBTSR program experienced significantly altered perceptions of their tinnitus. This included a reduction in depression and anxiety.
Most experts refer to tinnitus as the condition that causes ringing in the ears, however other abnormal sounds and sensations can also be attributed to tinnitus. The definition of tinnitus is “the perception of noise or ringing in the ears.” Some also describe this condition as “hearing sounds in the ears when no external sound is present.” Although tinnitus is only a significant problem for about 1 percent to 5 percent of the population, up to 10 percent to 15 percent of all children and adults are believed to experience ringing in the ears at least from time to time.

There is a growing body of evidence suggesting that some tinnitus is a consequence of neuroplastic alterations in the central auditory pathway. These alterations are assumed to result from a disturbed sensory input, caused by hearing loss.[28] Hearing loss could indeed cause a homeostatic response of neurons in the central auditory system, and therefore cause tinnitus.[29]


The best supported treatment for tinnitus is a type of counseling called cognitive behavioral therapy (CBT) which can be delivered via the internet or in person.[5][77] It decreases the amount of stress those with tinnitus feel.[78] These benefits appear to be independent of any effect on depression or anxiety in an individual.[77] Acceptance and commitment therapy (ACT) also shows promise in the treatment of tinnitus.[79] Relaxation techniques may also be useful.[3] A clinical protocol called Progressive Tinnitus Management for treatment of tinnitus has been developed by the United States Department of Veterans Affairs.[80]
A common cause of tinnitus is inner ear hair cell damage. Tiny, delicate hairs in your inner ear move in relation to the pressure of sound waves. This triggers cells to release an electrical signal through a nerve from your ear (auditory nerve) to your brain. Your brain interprets these signals as sound. If the hairs inside your inner ear are bent or broken, they can "leak" random electrical impulses to your brain, causing tinnitus.
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